Ctrl + Shift + Esc - Open task manager
Windows Key + R - run dialog
Winkey + D - toggle show desktop
Winkey + E - windows explorer
Winkey + L - lock workstation
Middle click a link - open in new background tab (useful for google, reddit)
Middle click a tab - close tab
Middle click back button - open history in new tab (not for IE)
Middle click a folder of favorites - open all favorites in new tabs
Ctrl + (shift +) tab - switch tab/document forwards (or backwards)
Alt + (shift +) tab - switch windows forwards (or backwards)
(Shift +) tab button - when filling out a form, skip to next (or previous) form field
Shift + Right click anywhere - usually adds ‘experienced user’ options (e.g. open cmd from here)
Hold Shift while inserting removable media - prevents ‘autorun’]
Shift + Delete - permanently deletes files (without going to recycle bin)
Ctrl + Scroll - zoom web page, document, file thumbnails
Ctrl + C on any standard error dialog box - copies error report text
Middle click an app on dock - Open new app
Middle click a thumbnail from dock - Close app
Shift + Right click dock item - Legacy menu
Drag up on dock item - Quick jumplist
Winkey + T - dock keyboard mode (use arrow keys)
Winkey + P - multi-display config quick-switch (press twice to switch)
Winkey + X - bring up laptop settings control panel
Winkey and + or - , zoom in/out of screen (awesome!)
Winkey + left, right, up or down key - manage window position
Winkey + appname + enter = run app
Winkey + tab - [Vista/7] flip3d
Winkey + [dos appname] + enter - [Vista/7] Launch without waiting for search results
Winkey + space - [win7] peek at desktop